C&EN

Cross-coupling preserves stereochemistry of chiral carboxylic acids

A new cross-coupling reaction weds chiral carboxylic acids, such as proline derivatives, to alkyl iodides while preserving ...
Nature

Exploration of 1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives effect on triple-negative breast, prostate cancer and melanoma cell 2D and 3D cultures

Cancer remains one of the major public health challenges today. According to data from the World Health Organization, nearly 10 million people died from this disease in 2020 1. Chemotherapy is the ...
BioWorld

Furan-2-carboxylic acid derivative shows improved anti-gluconeogenesis potency in vivo

Researchers from Shanghai Institute of Materia Medica presented the discovery of novel furan-2-carboxylic acid derivatives as potential candidates for the treatment of type 2 diabetes mellitus (T2DM).
Science Daily

Light-induced modification of a carboxylic acid with an aminocyclopropenone

Researchers report that carboxylic acids, functional groups contained in biomolecules, drugs, and materials can be readily modified by light-induced organic reactions using an aminocyclopropenone.
Nature

Hydroxamic acid derivatives as HDAC1, HDAC6 and HDAC8 inhibitors with antiproliferative activity in cancer cell lines

Histone deacetylases (HDACs) are a family of enzymes able to remove acetyl groups from lysine residues in histones and nonhistone proteins, which includes chaperone proteins and transcription factors, ...
JD Supra

Federal Circuit Holds That Claims of a Patent Asserted During a Patent Term Extension Are Not Infringed by the Carboxylic Acid Derivative of an FDA-Approved Ester Containing Drug

Recently, the Federal Circuit issued its holding in a case dealing with asserting claims of an extended patent covering administration of dimethyl fumarate formulations to treat multiple sclerosis (MS ...